HSP90 has been broadly studied as an important factor for GBM cell migration and invasiveness via activation of TLR-4; HSP70 confers resistance and prolongs the survival of GBM cells; Hsp 25, belonging to small HSPs with molecular weight ranging from 15 to 40 kDa, induces resistance to apoptosis [32]. The gene discussed is TLR4; the disease is glioblastoma.