GAPDH and hepatocellular carcinoma: Additionally, hepatocellular carcinoma cell lines with a migratory phenotype encapsulate more sugar metabolism-associated proteins in exosomes than their non-migratory counterpart, such as the glycolysis enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and proteins involved in glycolysis, gluconeogenesis, and the pentose phosphate pathway [101].