Gene expression of the primary adipogenic genes PPAR-γ (p < 0.001), LPL (healthy p < 0.05; lipedema p < 0.001), and Glut 4 (healthy p < 0.01; lipedema p < 0.001), were significantly increased in differentiated spheroids in both groups compared to undifferentiated spheroids (Figure 2B,C). Here, PPARG is linked to Lipedema.