The anaplastic lymphoma kinase (ALK) fusion gene is a rare driver aberration that occurs only in 2% to 7% of all non-small cell lung cancer (NSCLC) cases, with a predilection in never- or light-smokers and in patients with adenocarcinoma histology [1,2,3,4,5,6]. The gene discussed is ALK; the disease is adenocarcinoma.