ALK and non-small cell lung carcinoma: Our findings showed a relevant efficacy of lorlatinib for ALK-positive NSCLC even after multiple lines of treatment matching the results of the pivotal trial, with a median DoT of 4.4 months, median OS from lorlatinib start of 10.2 months, median OS from Stage III/IV of 41.8 months and an ORR of 43.2%.