High levels of HOXB9 are associated with poor prognosis in lung adenocarcinoma patients [12], low overall survival of colon cancer patients [49], high tumor grade and lower overall survival of breast cancer patients [50], advanced clinical stage of glioma patients [51], tumor progression, vascular and lymphatic invasion in gastric cancer patients [52], and vascular invasion and poor overall survival of hepatocellular carcinoma patients [13]. The gene discussed is HOXB9; the disease is malignant colon neoplasm.