In the chicken model of obesity, progression of cardiac functional failure by Ad-feed intake [5,6] was associated with a consistent increase of cardiac activating transcription factor 6 (ATF6) and CCAAT box binding enhancer homologous protein (CHOP) expression and transiently increased microtubule-associated protein 1 light Chain 3 beta (LC3B), and Sequestosome 1 (SQSTM1) expression early in obesogenic feeding, but was significantly downregulated at the late stage in overtly obese hens (p < 0.05, Figure 5). The gene discussed is SQSTM1; the disease is Obesity.