However, a low constitutive level of IL-1β in the heart, induced by mechanical stretch, was sufficient to induce IGF-1 (insulin-like growth factor-1) production that negatively regulated JNK (c-Jun N-terminal kinase) signaling in the progression of cardiomyocyte hypertrophy from the compensated state to heart failure [32]. The gene discussed is IL1B; the disease is heart failure.