In a rat study, black ginseng ameliorated hypercholesterolemia by attenuating mRNA levels of acetyl-coenzyme A (CoA) acetyltransferase 2, sterol regulatory element-binding protein 2, and 3-hydroxy-3-methyl-glutaryl-CoA reductase [28]. The gene discussed is SREBF2; the disease is Hypercholesterolemia.