In contrast, MSI-H mainly results from, but is not limited to, alterations of MMR genes (MLH1, MSH2, MSH6, and PMS2) [22], which do not involve the mechanism of CIN, so a limited association between CIN70 and MSI was found in the current study (Figure 3 and Supplementary Figure S2). Here, MLH1 is linked to cervical squamous intraepithelial neoplasia.