The aim of the study was to analyze the polymorphisms of the genes (DRD4 Ex3, DRD2 (rs1076560, rs1800498, rs1079597, rs6276, rs1799732), ANKK1 Tag1A rs1800497, DAT1) and co-occurrence of specific mental disorders in the group of patients diagnosed with polysubstance use disorder, including stimulants, compared to the group of patients diagnosed with polysubstance use disorder. This evidence concerns the gene SLC6A3 and mental disorder.