Circulating apelin concentration in patients was not independently associated with markers of liver disease including bilirubin (t = 0.015, p = 0.98), albumin (t = 1.81, p = 0.07), sodium (t = 0.91, p = 0.36), platelet count (t = 1.03, p = 0.31), creatinine (t = 0.4, p = 0.69) or prothrombin time (t = 0.47, p = 0.64) (Table 3). Here, F2 is linked to liver disorder.