Calcium_signaling_pathway, neuroactive_ligand_receptor_interaction and cytosolic_DNA_sensing_pathway are involved in breast cancer development [36–38] The melanoma pathway is an important cancer pathway that involves the cell cycle, transcriptional activation, and PI3K signaling pathway (https://www.genome.jp/kegg-bin/show_pathway?hsa05218), and it's well known that cell cycle and transcriptional activation are closely linked to tumorigenesis. The gene discussed is PIK3CA; the disease is cancer.