The mechanism for this role of CD3+ TILs in patients with NSCLC is that CD3 is the most common phenotype of TILs, CD8+ TILs also express the CD3+ phenotype, and CD8+TILs are a good prognostic marker for NSCLC, Therefore, we hypothesize that mainly CD3+CD8+ T cells play a synergistic role in promoting the prognosis for patients with NSCLC. Here, CD8A is linked to non-small cell lung carcinoma.