The results showed that a high density of CD4+ TILs in the TN indicated a better OS (HR = 0.88; 95% CI, 0.77–0.99; p<0.001) and DSS (HR = 0.75; 95% CI, 0.52–0.98; p<0.001) for patients with NSCLC. This evidence concerns the gene CD4 and non-small cell lung carcinoma.