Among 6,368 patients with dengue-like illness (DLI) admitted to the emergency department (ED) of NCKUH in 2015, 2,942 cases (46.20%) were confirmed to have dengue due to one or more positive results with dengue-NS1, IgM, PCR, or viral load of DENV tests, i.e. the “confirmed dengue group”. Here, CD40LG is linked to dengue disease.