Using multivariable logistic regression analyses, preexisting liver disease (AOR: 42.01, 95% CI: 4.22–417.49), taking other hepatotoxic drugs (AOR: 23.66, 95% CI: 1.77–314.79), and having lower serum albumin (AOR: 10.55, 95% CI: 2.57–43.32) were found to be significantly associated with the development of anti-tuberculosis drug-induced hepatitis. This evidence concerns the gene ALB and liver disorder.