Intramyocellular lipid storage is also known to impair insulin action in skeletal muscle, contributing to the pathogenesis of type 2 diabetes (42), whereas lipid deposition in the vascular intima results in progression to complex atherosclerotic lesions, predisposing the patients to cardiovascular diseases, such as myocardial infarction and stroke (43). This evidence concerns the gene INS and myocardial infarction.