Importantly, in addition to the direct impact of STK25 on diet-induced renal steatosis and kidney injury described in this study, our previous investigations have revealed that STK25 also critically controls lipid accumulation, metainflammation, and nutritional fibrosis in liver, pancreas, skeletal muscle, and aorta in the context of obesity (10–17). The gene discussed is STK25; the disease is obesity due to melanocortin 4 receptor deficiency.