Recently, Weng et al. demonstrated that GM-CSF attenuates MYC-associated gene signatures in t (8;21) (RUNX1-ETO) leukemia cells, but not in control cells by restoring the expression of a subset of MYC-repressed targets (e.g. CEBPA), which promote a myeloid differentiation and apoptosis [26]. The gene discussed is RUNX1; the disease is leukemia.