GAL and gastric cancer: Our previous work demonstrated that GAL-1 can promote VM formation in GC by upregulating epithelial-mesenchymal transition (EMT) signaling [15], and that GAL-1 can induce EMT through upregulation of Hedgehog (Hh) signaling via Glioma-associated oncogene-1 (GLI1) in GC [16, 17].