Genes related to tumor progression, including matrix metallopeptidase 1 or MMP1 [27], S100 calcium binding protein A2 or S100A2 [28], tetraspanin 8 or TSPAN8 [29], and insulin like growth factor binding protein 7 or IGFBP7 [30] were upregulated in GSM3516665-subgroup 2 (Figure 7G). The gene discussed is IGFBP7; the disease is neoplasm.