IGFBP2 and familial pancreatic carcinoma: For example, clusterin (CLU) is associated with chemoresistance and tumor proliferation in pancreatic cancer [34]; insulin like growth factor binding protein 2 or IGFBP2 [35] is related to signaling pathways associated with tumor cell migration; heat shock protein 90 beta family member 1 or HSP90B1 [36] correlates with poor prognosis and lymph node metastases in melanoma.