MAPT and Alzheimer disease: In AD, tau aggregated in the neurofibrillary tangles (NFTs) is aberrantly hyperphosphorylated and several phosphorylated sites have been identified (Grundke‐Iqbal et al, 1986; Ksiezak‐Reding et al, 1988; Goedert et al, 1988, 1989; Lee et al, 1991, 2001).