In addition to the aforementioned role of VH⁢1⁢-⁢69 in broadly neutralizing anti-influenza and anti-HIV antibodies (Haynes et al., 2005; Mouquet et al., 2011; Andrews et al., 2015; Prigent et al., 2018), autoreactive chronic lymphocytic leukemic B cells commonly express receptors bearing VH⁢1⁢-⁢69 (Sasso et al., 1993; Forconi et al., 2010), and anti-HIV antibodies which target the membrane-proximal external region of HIV-1 envelope glycoproteins frequently utilize VH⁢1⁢-⁢69 (IAVI Protocol G Investigators et al., 2019). This evidence concerns the gene ERVW-1 and influenza.