EVPL and leukemia: Earlier studies have shown that p190 and p210 induce distinct leukemia phenotypes in mouse models [18, 53], In concord, we noted phenotypic preferences of different isoforms in colonogenic assay of HPC-LSK cells, where p190 was associated with stem-like phenotype and increased tendency for lymphoid development in contrast with myeloproliferative phenotype of p210.