Although the transcriptional profiles of CML patient samples demonstrated notable clustering according to the Bcr-Abl isoform type (Fig. 1b, Supplementary Fig. 1a), only few genes (n = 14) were identified as differentially expressed (DE) and were all upregulated in p190-CML compared to p210-CML samples. This evidence concerns the gene CNTNAP1 and chronic myelogenous leukemia, BCR-ABL1 positive.