Gene set enrichment analysis revealed significant upregulation of TNF signaling via NFKB, interferon (IFN) alpha and gamma responses, IL1R, apoptosis and P53 pathways in p190-CML in comparison with p210-CML patients (Fig. 1d, Supplementary Fig. 1c, Supplementary Table 3). This evidence concerns the gene NFKB1 and chronic myelogenous leukemia, BCR-ABL1 positive.