Using WES, we identified 46 variants in p190-CML samples (median per patient = 9.5, range: 4–26), including potentially relevant variants in ASXL1, DNMT3A, and KDM4D epigenetic modifier genes (Fig. 1a, Supplementary Table 3). This evidence concerns the gene DNMT3A and chronic myelogenous leukemia, BCR-ABL1 positive.