SRC and chronic myelogenous leukemia, BCR-ABL1 positive: In addition, TKIs exerting Src-kinase inhibitory activity (ex: dasatinib, bosutinib, saractinib) exhibited a trend of enhanced sensitivity in p190 cells (Fig. 4a-b, Supplementary Fig. 4a) in accordance with noted Src hyperphosphorylation in p190-CML patient cells and cell line models.