We then categorized the tumor samples based on the calculated weighted genome integrity index (wGII) into low and high CIN groups and correlated the status of CIN with the expression level of CDKN1A. Interestingly, there was a significant correlation between low CDKN1A expression and the presence of chromosomal instability (Fig. 6d, Fig. S10b). The gene discussed is CDKN1A; the disease is cervical squamous intraepithelial neoplasia.