To test whether unleashed CDK1 activity can act as a trigger for increased microtubule polymerization rates and subsequent chromosome missegregation in human cancer cells we analyzed a panel of colorectal cancer (CRC) cell lines characterized by either MIN/MSI (chromosomally stable, nearly diploid) or W-CIN (chromosomally unstable, aneuploid). This evidence concerns the gene CDK1 and colorectal cancer.