It is of note that we were not able to consistently associate alterations in p53, p73, p21CIP1 or CDK1 protein levels with increased microtubule polymerization rates in the different W-CIN cell lines (Fig. S9) suggesting that various mechanisms and alterations might contribute to CDK1 deregulation in human cancer cells (see model in Fig. 7). This evidence concerns the gene CDK1 and cancer.