IGFBP3 and hypertensive disorder: Six genes surpass a gene-based adjusted threshold for significance (Bonferroni adjusted p value < 1e−6) in all analyses: CNTNAP2, previously found to be associated with SBP and DBP in Mexican Americans [35]; MACROD2, associated with DBP in a multiethnic cohort [36]; CSMD1 and WWOX, associated with hypertension in Asian populations [37, 38]; DPP6, which contributes to transient outward current in Purkinje fibers [39]; SORCS2, associated with concentrations of IGFBP-3, a vasodilator [40, 41].