We evaluated a total of 6 non-tumoral pituitaries and 42 PA: 20 (47.6%) were non-functioning adenomas (14 gonadotrophinomas, 3 null cell adenomas and 3 silent ACTH-secreting adenomas); 10 (24%) were GH-secreting adenomas; 2 (4.7%) were prolactinomas, 4 (9.5%) were TSH-secreting adenomas and 6 (14.2%) were clinically manifest ACTH-secreting adenomas (Cushing disease). This evidence concerns the gene POMC and adenoma.