Our transcriptomic and methylomic results, as well as our pathway analysis findings support the notion that there at least three different TSC populations from which three distinct types of PA develop, based on their canonical transcription factors, namely, TBX19-driven corticotrophiomas, NR5A1-dependent CNFPA (gonadotrophinomas and null cell adenomas) and POU1F1-dependent GH-, PRL and TSH adenomas3. The gene discussed is POU1F1; the disease is tuberous sclerosis.