IRAK3 and keratoconus: To further investigate the interactions between the identified DE miRNAs and the 72, 41, and 175 differentially expressed (DE) genes that were previously identified in the same liver tissues of the same three animal populations18, we identified only 1 (GNAZ), 2 (THEM4 and CES1), and 5 (PALMD, C12orf45, IRAK3, CITED4, and IL20RA) out of the 72, 41, and 175 DE genes as targeted DE genes for the DE miRNAs, respectively, in the Angus, Charolais, and KC breed populations using a TargetScan context++ score percentile threshold of 99 for each breed populaton.