KMT2C (MLL3; Fig. 3D) is a lysine methyltransferase part of the COMPASS family mainly creating H3K4me1 on enhancers54,55.The gene is located in a region on chromosome 7 that is often deleted in myeloid leukemia56 and proposed to act as a tumor suppressor. The gene discussed is KMT2C; the disease is neoplasm.