The inferred subset GRN from the PC3 prostate cancer cell line (Supplementary Fig. 47) suggests several genes as suppressors of SDHB, such as PNKB, PWP1, PNP, HADH, HTATSF1, and BAZ1B, among which PWP1, HTATSF1, and BAZ1B are transcription regulators. The gene discussed is HTATSF1; the disease is Familial prostate cancer.