Protein misfolding and aggregation are at the heart of neurodegenerative processes and can occur extracellularly as well as in the cytosol, the latter being evidenced by reported aggregation of various cytosolic proteins, including α-synuclein (Parkinson’s disease and other synucleinopathies), tau (Alzheimer’s disease and tauopathies), and TDP-43 (amyotrophic lateral sclerosis and frontotemporal dementia) (1). The gene discussed is SNCA; the disease is synucleinopathy.