MECP2 and autism: Ras-MAPK genes are dysregulated in MECP2-duplication mice (Chahrour et al., 2008), mutations in Ras-MAPK pathway genes are linked to several forms of autism (Stornetta and Zhu, 2011), and several autism models have been shown to have abnormal Ras-MAPK signaling (Ebert and Greenberg, 2013).