ALDH3A2 and Sjogren-Larsson syndrome: One of the most recognized of these conditions, Sjögren–Larsson syndrome (SLS: MIM#270200), is typically caused by mutations in the ALDH3A2 gene encoding for fatty acid aldehyde dehydrogenase and characterized by congenital ichthyosis, leukoencephalopathy, intellectual disability, and spastic di- or tetraplegia [7].