PRKN and Parkinson disease: Therefore, the transcriptional roles as well as the mitophagic roles of PARKIN should be considered in PD as well as other neurodegenerative conditions.A Pink1 KO mouse model in which the pathogenic patient mutation G309D was inserted into exon 5 presented mitochondrial dysfunction leading to defects in ATP generation along with a reduction in dopamine in the nigrostriatal projection with a concurrent reduction in locomotor activity, but again without neurodegeneration [132].