APOE and Alzheimer disease: Our analysis demonstrated that a base model encompassing the best validated constitutional risk factors for AD in a preclinical group (age, sex and APOE4 carriership) performed well (AUC 0.82) in predicting AD pathology, with the model being considerably less accurate for AD pathologic change and non-AD pathology (AUCs 0.63 and 0.63, respectively), and particularly combined AD and non-AD pathologic change (AUC 0.56).