MAPT and diabetes mellitus: In terms of cardiovascular risk factors, we found evidence for lower BMI associating with tau pathology (OR = 0.94, 95% CI 0.90–0.98, p = 0.01) whereas amyloid pathology was linked to lower use of hypertensive therapy, lack of diabetes diagnosis and increased WML volumes relative to no pathology (OR = 0.64, 95% CI 0.43–0.95, p = 0.03; OR = 0.39, 95% CI 0.18–0.85, p = 0.02; OR = 1.010, 95% CI 1.005–1.014, p < 0.001).