A closer examination of this effect showed that APOE4 carriers were younger than non-carriers in participants with normal AD biomarkers (61.8 ± 6.1 vs 65.0 ± 6.7 years), while APOE4 carriers were older than non-carriers among those with Alzheimer’s pathologic change (65.2 ± 6.5 vs 64.1 ± 7.8 years). This evidence concerns the gene APOE and Alzheimer disease.