For the prediction of each ATN pathology group relative to no pathology, the following logistic regression models were run: model 1: age, sex and APOE4 status (including an age X APOE4 interaction term for Alzheimer’s pathologic change); model 2: model 1 plus family history; model 3: model 1 plus BMI; model 4: model 1 plus WML volume; model 5: model 1 plus MMSE; model 6: all preceding risk factors; and model 7a, b and c: model 1 plus each composite risk score (Table 4). The gene discussed is APOE; the disease is oculocutaneous albinism type 1.