In terms of constitutional risk factors, we found that age and APOE4 carriership both increased the risk of amyloid (OR = 1.03, 95% CI 1.02–1.05, p < 0.001; OR = 2.24, 95% CI 1.68–2.98, p < 0.001) and tau pathology, respectively (OR = 1.11, 95%CI 1.08–1.14, p < 0.001; OR = 2.00, 95% CI 1.38–2.90, p < 0.001), while the family history of dementia associated with tau positivity only (OR = 1.55, 95%CI 1.04–2.32, p = 0.03). The gene discussed is APOE; the disease is dementia.