By analyzing 155 stage IV patients affected by different types of cancers using next-generation sequencing (NGS), Kato et al. observed that in a cohort of 155 patients with advanced cancers, 49 (31.6%) had a TTF < 2 months; 6 of them had MDM2/MDM4 amplifications that were found to be an independent predictor of poor clinical outcome by multivariate analysis. This evidence concerns the gene MDM4 and cancer.