Consistently, significantly higher levels of molecules representing CD8+ T-TIL activation and function were observed in DLBCL patients with higher miR-340-5p or lower KMT5A expression, while lower miR-340-5p or higher KMT5A expression implied fewer functional molecules of CD8+ T-TILs (Fig. 5a-b). Here, KMT5A is linked to diffuse large B-cell lymphoma.