In turn, top positively correlated modules were significantly enriched for “Top Human Microglia-Specific Genes”, and more specifically “Immune Response”, “Genes Correlated with Trem2”, and genes “Upregulated in AD-associated Microglia (Keren-Shaul et al., 2017)” (Fig. 2d). The gene discussed is TREM2; the disease is Alzheimer disease.