Here, we have studied the interaction between dietary (TWD) and genetic factors (APPswe/PS1dE9 and Tau P301L mutations) and their effects on memory, brain pathology, and global gene expression in female mice with WT (AwTw) and different AD- and tauopathy-linked genetic backgrounds: Tau P301L (AwT+), APPswe/PS1dE9 (A+Tw), and triple transgenic APPswe/PS1dE9/Tau P301L (A+T+). This evidence concerns the gene MAPT and Alzheimer disease.