Pathway enrichment was then performed to further narrow down to the linker genes that were specifically involved in IDC of breast and the genes identified here were SMAD4, EP300, PIK3CA, TP53, HIF1A and AKT1. SMAD4 has been known to be mainly involved in pancreatic and colorectal cancer [76]. The gene discussed is AKT1; the disease is colorectal cancer.