A significantly higher serum CRP concentration (Fig. 2) was observed in the stage D of CHF (median/interquartile range: 37.8/26.9–60.9 μg/mL) compared with stage A (median/interquartile range 2.1/1.5–10.9 μg/mL, P < 0.05) and with stage B2 dogs (median/interquartile range 4.3/1.0–9.7 μg/mL, P < 0.05). The gene discussed is CRP; the disease is congestive heart failure.