EP300 and neoplasm: While mice bearing xenografts of MDA-MB-231WT and scramble cells developed large tumors within three weeks of cell injection, tumors in MDA-MB-231EP300KD cell xenograft bearing mice barely grew (tumor volume: WT 756.34 ± 58.34 mm3 scramble 978.18 ± 155.87 mm3, EP300 KD clone 1 31.54 ± 10.67 mm3, EP300 KD clone 2 68.17 ± 10.28 mm3) (Fig. 3a and b).