LMNB2 and colorectal cancer: For example, both PCA ordering and inferred tuned positions can be used to characterize the changes in the radial CT organization in a perturbed (e.g. relocation of CTs during DNA damage response [78]) or diseased cell (e.g. mislocalization of CT18 and CT19 in lamin B2 depleted colorectal cancer cells [79]) compared to a control cell, which in turn allows us to study how these changes affect higher-order chromatin structure.