The findings that MEF2 co-localized with p62, which is a marker of inclusions, within the muscular fibers of R6/2 mice, and that the recombinant protein GFP-74Q Huntingtin was co-immunoprecipitated with MEF2, raised the hypothesis that the inclusion of MEF2 within the polyQ-Huntingtin aggregates impairs its function of transcriptional regulator, contributing to the muscular atrophy found in HD [87]. This evidence concerns the gene HTT and muscular atrophy.