In the hindlimb muscle from 12 months old YAC128 and in 12 weeks old R6/2 mice, the caspase-6 activity was increased compared to control animals; in addition, in post-mortem muscle tissues from HD patients there was an increased fragmentation of lamin A, that is a known caspase-6 target [123]. This evidence concerns the gene CASP6 and Huntington disease.