HTT and Huntington disease: As a matter of fact, studies based on oligonucleotide microarrays performed on muscles extracted from animal models of HD and HD patients reported increased mRNA levels of genes that encode chaperones, heat shock proteins, proteasomal-subunits, ubiquitin-conjugating enzymes and multiple DNA-repair enzymes, supporting the hypothesis of a cellular reaction to the toxicity related to Huntingtin aggregates [29,74].