ALS may be categorized as sporadic ALS (sALS; 90% of cases) or familial ALS (fALS; 10% of the cases) which is linked to mutations in a large variety of apparently unrelated genes [5] although mutations in SOD1, TARDBP, FUS and C9orf72 are collectively present in more than 50% of fALS cases [6]. Here, TARDBP is linked to amyotrophic lateral sclerosis.