The modification (deletion+insertion) at the N-ter of gD constitutes a platform for the generation of fully retargeted oHSVs, as was demonstrated by the engineering of different scFvs directed to EGFR (oHSV R-611), PSMA (oHSV R-593) and EGFRvIII, a glioma-specific variant of EGFR (oHSV R-613) [127]. Here, EGFR is linked to central nervous system cancer.