EIF2AK2 and neoplasm: First, the attenuation of Δγ134.5 recombinants was reduced, and the viruses displayed increased virus replication and improved lysis of tumor cells [46]: this effect depends on the new kinetic of expression of US11 (normally a late gene, now an immediate-early gene under control of US12 promoter), which precludes the phosphorylation of eIF-2α, curtailing the PKR pathway of shutoff of protein synthesis.