Also, upon myocardial infarction, a greater deterioration in cardiac function was observed in Eng+/− compared to control mice, although host inflammatory leukocyte numbers in the infarct area were similar; however, defects in vessel formation and heart function in Eng+/− mice were rescued by injection of leukocytes from healthy human donors, but not by leukocytes from HHT1 patients [101]. This evidence concerns the gene ENG and myocardial infarction.