CCND1 and gastric cancer: Furthermore, as shown in studies of Song et al. [62], PL inhibited the proliferation, cell cycle progression, as well as invasion and migration of MKN-45 and AGS gastric cancer cells through suppression of the JAK/STAT signaling pathway and downregulation of the expression of target genes of STAT-3, such as Ki-67 (a proliferation marker), cyclin D1 (a cell cycle regulator), MMP-9, and Twist (a EMT markers).