Furthermore, some studies showed IL-8 or chemokine (C-X-C motif) ligand 8 (CXCL8) receptor, C-X-C Motif Chemokine Receptor 1 (CXCR1) or CXCR2, altered CARs significantly enhance the invasion and persistence of T cells in cancer environment [137]. This evidence concerns the gene CXCL8 and cancer.