Basically, these natural compounds, such as the triptonide, were effective in inhibiting tumorigenicity and tumor growth in a wide variety of cancers, including pancreatic cancer and thyroid induced metastases by activating the tumor-suppressive MAPK (mitogen-activated protein kinase) signaling pathway and via astrocyte elevated gene-1, respectively [98,99]. Here, WNK2 is linked to thyroiditis.