Of the eight compounds that showed the inhibitory kinase activity against FLT3-ITD and FLT3-D835Y in vitro, five compounds (7c, 5c, 4c, 2c, and 6c) inhibited the growth of Molm-13 and MV4-11 cells at 100 nM, but not that of AML HL-60 (FLT3-null) cells at 10,000 nM (Table 1) and human chronic myeloid leukemia K562 cells (FLT3 WT) at 1000 nM (Figure S1). This evidence concerns the gene FLT3 and acute myeloid leukemia.