HIF1A and hereditary leiomyomatosis and renal cell cancer: The ULMs of patients with HLRCC are more vascularized and show more overexpression of HIF1α and vascular endothelial growth factor (VEGF) than do sporadic leiomyomas [35,36], and this should be considered by gynaecologists to prevent haemorrhagic complications at the time of surgery.