MC4R and Fever: Of note, the study that used ontology-based literature mining identified several other genes that have not yet been investigated in the scope of MMR vaccine adversomics as high ranking in both vaccine and fever networks (i.e., IL1B, TNF, IL-6, and CD8A), and in only fever networks (HSPA1A, NFKB1, IL-8, IL-2, MEFV, MAPK1, POMC, CD4, and IL-10), and in only vaccine networks (CSF2, IL7R, ERVWE1, APC, MC4R, IL1R1, and TLR2) [72].