The anti-smooth-muscle antibody-positive non-responders all carried the supratype HLA-C4AQ0, DRB1*0301, DQB1*02, which has been associated with poor HBV response in other studies [17,18,20] and is a well-known predisposing factor for autoimmune disorders. The gene discussed is HLA-DRB1; the disease is autoimmune disease.