Synthetic cannabinoids WIN-55,212-2 and JWH-133 have also been linked with the inhibition of growth and metastasis of LC cells in vitro and in vivo by blockage of Akt phosphorylation and lowering the levels of matrix metalloproteinase-9 (MMP9) [119]. Here, MMP9 is linked to laryngotracheoesophageal cleft.