The activation of cannabinoid receptors on melanoma cells can lead to G1-cell cycle arrest by the inhibition of Akt and pRb signalling molecules, activation of caspase-3, stimulation of ROS production, and inhibition of the expression of EGF and VEGF, which in turn lowers the proliferation and metastatic potential of melanoma cells [155]. The gene discussed is VEGFA; the disease is melanoma.